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A community effort to collect a curated set of analysis pipelines built using Nextflow.

This repository holds the official source codes for the paper An Interpretable Graph-Regularized Optimal Transport Framework for Diagonal Single-Cell Integrative Analysis (GROTIA). It is a framework for joint analysis of unpaired scRNA-seq and scATAC-seq data. It provides two core capabilities:

1. GROTIA learns interpretable, modality-specific embeddings that project RNA and ATAC into a shared low-dimensional space while attaching an importance score to every gene or peak.
2. GROTIA converts the ...

Space to share Rare Disease Analyses