Teams

Melbourne Bioinformatics enables cutting edge research through the power of data. We train the specialists and build the infrastructure needed to understand some of society’s biggest challenges, from cancer to climate change.

We are a team of Academic Specialists who collaborate with researchers to enable data-intensive research across the University. We work with researchers at all stages of the research lifecycle, from research design and data collection, all the way through to analysis, visualisation, and interpretation.

Automated pipeline for generating residue-level lipid contact annotations from PDB structures. The workflow queries RCSB PDB for structures containing lipid chemical components (117 recognized codes), downloads original PDB files, calculates all-atom heavy-atom contacts at 4.0 Angstrom cutoff, clusters sequences at 30% identity using MMseqs2, and partitions into train/validation/test splits. Produces a complete dataset of 4,704 proteins with 8,055,325 annotated residues.

Research areas: - Structure, evolution and maintenance of telomeres and their roles in chromosome stability, DNA repair and plant speciation - Epigenetic mechanisms in the regulation of gene expression, chromatin assembly, genome stability and telomere homeostasis - Transcription, replication and DNA repair in the context of nuclear and nucleolar architecture

This team is dedicated to the development of the Meta-NanoSim tool: https://github.com/bcgsc/nanosim